Annotation Detail
Information
- Associated Genes
- MYC
- Associated Variants
- MYC UNDEREXPRESSION
- Source Database
- MMMP
- Description
- Specific c-Myc inhibition increased melanoma susceptibility to antineoplastic drugs with different mechanisms of action, such as cisplatin (CDDP), staurosporine (STR), and 5-fluorouracil (5-FU). The effect of MYC is mediated by its target gene g-GCS (glutathione synthesis)
- MMMP State
- downregulated by
- MMMP Molecule
- MYC
- MMMP Molecule Alias
- c-Myc
- MMMP Modifier
- MYC antisense oligo
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Staurosporine
- MMMP Model
- 3
- MMMP Reference
- Benassi B, Mol Pharmacol 2007, 72:1015-23
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Staurosporine | Sensitivity | true |