Annotation Detail
Information
- Associated Genes
- MGMT
- Associated Variants
- MGMT OVEREXPRESSION
- Source Database
- MMMP
- Description
- Determination of O6-methylguanine-DNA methyltransferase (MGMT) activity showed that MeWo cells that acquired resistance to fotemustine upon repeated treatment with the drug display high MGMT activity, whereas the parental cell line had no detectable MGMT
- MMMP State
- active (high activity)
- MMMP Molecule
- MGMT
- MMMP Molecule Alias
- O-6-methylguanine-DNA methyltransferase
- MMMP Relationship
- resistance to
- MMMP Drug
- Fotemustine
- MMMP Model
- 3
- MMMP Reference
- Christmann M, Int J Cancer 2001, 92:123-9
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Fotemustine | Resitance or Non-Reponse | true |