Annotation Detail
Information
- Associated Genes
- AKT1
- Associated Variants
- AKT1 UNKNOWN
- Source Database
- MMMP
- Description
- Akt-DN: dominant negative AKT. Authors used different cell lines: one melanoma cell line with low AKT activity was resistant to treatment; those with high AKT activity were sensitive
- MMMP State
- phosphorylated (Ser-473)
- MMMP Molecule
- AKT
- MMMP Molecule Alias
- PKB
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Akt-DN gene therapy
- MMMP Model
- 3
- MMMP Reference
- Jetzt A, Cancer Res 2003, 63:6697-706
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Akt-DN gene therapy | Sensitivity | true |