Annotation Detail

Information
Associated Genes
AKT1
Associated Variants
AKT1 UNKNOWN
Source Database
MMMP
Description
Wortmannin is a PI3K inhibitor (PI3K activates AKT by phosphorylation). Constitutive activation of Akt in melanoma leads to upregulation of NFkB and tumor progression
MMMP State
phosphorylated (Ser-473)
MMMP Molecule
AKT
MMMP Molecule Alias
PKB
MMMP Relationship
sensitivity to
MMMP Drug
Wortmannin
MMMP Model
3
MMMP Reference
Dhawan P, Cancer Res 2002, 62:7335-42
MMMP DNA/mRNA/Protein
protein
Drugs
Drug NameSensitivitySupported
WortmanninSensitivitytrue