Annotation Detail
Information
- Associated Genes
- AKT1
- Associated Variants
- AKT1 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- MEK1/2 plays an important role in TNFalpha-resistance and is more important than NFkB, Akt, and p38MAPK in anti-apoptotic PKC signaling; TNFalpha-resistance can be overcome by inhibiting MEK1/2
- MMMP State
- inhibited by
- MMMP Molecule
- AKT
- MMMP Molecule Alias
- PKB
- MMMP Modifier
- LY294002
- MMMP Relationship
- no relationship with
- MMMP Drug
- TNF
- MMMP Drug Alias
- Tumor necrosis factor
- MMMP Model
- 1
- MMMP Reference
- Nishida S, Life Sci 2003, 74:781-92
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| TNF | Resitance or Non-Reponse | true |