Annotation Detail
Information
- Associated Genes
- ROS1
- Associated Variants
- ROS1 OVEREXPRESSION
- Source Database
- MMMP
- Description
- The consistent synergy seen for imexon and alkylating agents may relate to the sulfhydryl-lowering effect of imexon, which would render cells more sensitive to electrophilic species from the alkylators
- MMMP State
- upregulated by
- MMMP Molecule
- ROS
- MMMP Molecule Alias
- Reactive oxygen species
- MMMP Modifier
- Imexon
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Dacarbazine
- MMMP Drug Alias
- DTIC
- MMMP Model
- 3
- MMMP Reference
- Scott J, Cancer Chemother Pharmacol 2007, 59:749-57
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Dacarbazine | Sensitivity | true |