Annotation Detail
Information
- Associated Genes
- ROS1
- Associated Variants
- ROS1 OVEREXPRESSION
- Source Database
- MMMP
- Description
- ET-743 is believed to act through formation of anion superoxide in proximity of DNA with consequent DNA damage and induction of apoptosis
- MMMP State
- upregulated by
- MMMP Molecule
- ROS
- MMMP Molecule Alias
- Reactive oxygen species
- MMMP Modifier
- Trabectedin
- MMMP Modifier Alias
- ET-743, Yondelis (R)
- MMMP Relationship
- sensitivity to
- MMMP Drug
- Cisplatin
- MMMP Drug Alias
- CDDP
- MMMP Model
- 4
- MMMP Reference
- D'Incalci M, Eur J Cancer 2003, 39:1920-6
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Cisplatin | Sensitivity | true |