Annotation Detail
Information
- Associated Genes
- ATF4
- Associated Variants
- ATF4 UNDEREXPRESSION
- Source Database
- MMMP
- Description
- siRNA-mediated knockdown of ATF4 resulted in a a significant reduction in fenretinide-, bortezomib- or thapsigargin-induced cell death in A375 cells with reduced ATF4 expression, and there was evidence for increased death of A375 cells overexpressing ATF4 in response to treatment with these agents
- MMMP State
- downregulated by
- MMMP Molecule
- ATF4
- MMMP Modifier
- ATF4 siRNA
- MMMP Relationship
- resistance to
- MMMP Drug
- Fenretinide
- MMMP Model
- 3
- MMMP Reference
- Armstrong JL, J Biol Chem 2010, 285:6091-100
- MMMP DNA/mRNA/Protein
- mRNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Fenretinide | Resitance or Non-Reponse | true |