Annotation Detail
Information
- Associated Genes
- MGMT
- Associated Variants
- MGMT OVEREXPRESSION
- Source Database
- MMMP
- Description
- The O(6)-methylguanine-DNA methyltransferase (MGMT) activity in the cell lines was between 0 and 1100 fmol mg(-1) protein, and there was a correlation between MGMT activity and the level of resistance to TMZ and fotemustine
- MMMP State
- active (high activity)
- MMMP Molecule
- MGMT
- MMMP Molecule Alias
- O-6-methylguanine-DNA methyltransferase
- MMMP Relationship
- resistance to
- MMMP Drug
- Temozolomide
- MMMP Drug Alias
- TMZ
- MMMP Model
- 3
- MMMP Reference
- Naumann SC, Br J Cancer 2009, 100:322-33
- MMMP DNA/mRNA/Protein
- protein
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Temozolomide | Resitance or Non-Reponse | true |