Annotation Detail
Information
- Associated Genes
- MGMT
- Associated Variants
- MGMT K178R
- Source Database
- MMMP
- Description
- There was no evidence that these variants decreased the MGMT DNA repair activity compared to the wild-type protein
- MMMP State
- polymorphism K178R
- MMMP Molecule
- MGMT
- MMMP Molecule Alias
- O-6-methylguanine-DNA methyltransferase
- MMMP Relationship
- no relationship with
- MMMP Drug
- Dacarbazine based chemotherapy
- MMMP Model
- 5
- MMMP Reference
- Ma S, Br J Cancer 2003, 89:1517-23
- MMMP DNA/mRNA/Protein
- DNA
Drugs
| Drug Name | Sensitivity | Supported |
|---|---|---|
| Dacarbazine based chemotherapy | Resitance or Non-Reponse | true |