Annotation Detail
Information
- Associated Genes
- MPO
- Associated Variants
-
MPO MUTATION
MPO MUTATION - Associated Disease
- rheumatoid arthritis
- Source Database
- DisGeNET
- Description
- Neutrophils from RA cases exhibited increased spontaneous NET formation in vitro, associated with elevated ROS production, enhanced NE and MPO expression, nuclear translocation of PAD4, PAD4-mediated citrullination of H3, and altered nuclear morphology.
- Pubmed
- 24928093
- Section of the abstract supporting the evidence
- RESULTS
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 8
- Original source reporting the Gene Disease association
- BeFree,CTD_human
- DisGENET score for the Gene Disease association
- 0.120542883744161
Drugs