Annotation Detail
Information
- Associated Genes
- APOA1
- Associated Variants
-
APOA1 MUTATION
APOA1 MUTATION - Associated Disease
- arteriosclerosis
- Source Database
- DisGeNET
- Description
- In contrast to hereditary amyloidosis, wherein specific mutations of apoA-I cause protein destabilization and amyloid deposition, oxidative conditions similar to those promoted by local inflammation in atherosclerosis are sufficient to transform full-length wild-type apoA-I into an amyloidogenic protein.
- Pubmed
- 25759391
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 12
- Original source reporting the Gene Disease association
- BeFree,LHGDN,RGD
- DisGENET score for the Gene Disease association
- 0.0992823044393657
Drugs