Annotation Detail
Information
- Associated Genes
- CTSS
- Associated Variants
-
CTSS MUTATION
CTSS MUTATION - Associated Disease
- aortic aneurysm
- Source Database
- DisGeNET
- Description
- These findings support a role for osteoprotegerin in aortic aneurysm through upregulation of CTSS, matrix metalloproteinase 2, and matrix metalloproteinase 9 within the aorta, promoting an inflammatory phenotype in aortic vascular smooth muscle cells in response to angiotensin II.
- Pubmed
- 25301844
- Section of the abstract supporting the evidence
- CONCLUSIONS
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 9
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs