Annotation Detail
Information
- Associated Genes
- SEC16B
- Associated Variants
-
MTCH2 c.540-395G>A
(
ENST00000530428.2,
ENST00000302503.8 )
NC_000012.12:g.49853685G>A
MTIF3 c.-112-906C>T ( ENST00000381116.5, ENST00000381120.8 )
MAP2K5 c.1243-12146G>A ( ENST00000178640.10, ENST00000354498.9, ENST00000340972.8, ENST00000395476.6 )
FTO c.46-40478T>A ( ENST00000637969.1, ENST00000637001.1, ENST00000471389.6, ENST00000636491.1, ENST00000636218.1 )
rs571312
rs543874
TNNI3K c.2352-14274A>G, FPGT-TNNI3K c.2655-14274A>G ( ENST00000326637.8, ENST00000557284.7 )
rs2867125
RPS10-NUDT3 c.567+6770T>C, NUDT3 c.210+6770T>C ( ENST00000607016.2, ENST00000639725.1, ENST00000639877.1 )
TFAP2B c.602-724A>G ( ENST00000393655.4 )
LINGO2 c.-227-41473T>C ( ENST00000379992.6, ENST00000698399.1, ENST00000698400.1, ENST00000698401.1, ENST00000698402.1, ENST00000698403.1 )
MTCH2 c.540-395G>A ( ENST00000302503.8, ENST00000530428.2 )
NC_000012.12:g.49853685G>A
MTIF3 c.-112-906C>T ( ENST00000381116.5, ENST00000381120.8 )
MAP2K5 c.1243-12146G>A ( ENST00000178640.10, ENST00000340972.8, ENST00000354498.9, ENST00000395476.6 )
FTO c.46-40478T>A ( ENST00000471389.6, ENST00000636218.1, ENST00000636491.1, ENST00000637001.1, ENST00000637969.1 )
rs571312
rs543874
TNNI3K c.2352-14274A>G, FPGT-TNNI3K c.2655-14274A>G ( ENST00000326637.8, ENST00000557284.7 )
rs2867125
RPS10-NUDT3 c.567+6770T>C, NUDT3 c.210+6770T>C ( ENST00000607016.2, ENST00000639725.1, ENST00000639877.1 )
TFAP2B c.602-724A>G ( ENST00000393655.4 )
LINGO2 c.-227-41473T>C ( ENST00000379992.6, ENST00000698399.1, ENST00000698400.1, ENST00000698401.1, ENST00000698402.1, ENST00000698403.1 ) - Associated Disease
- obesity
- Source Database
- DisGeNET
- Description
- Eight loci, rs10968576 (BDNF), rs3817334 (MTCH2), rs1558902 (FTO), rs571312 (MC4R), rs543874 (SEC16B), rs987237 (TFAP2B), rs2867125 (TMEM18) and rs7138803 (FAIM2), were previously known obesity susceptibility loci, and the remaining four loci, rs1514175 (TNNI3K), rs206936 (NUDT3), rs4771122 (MTIF3) and rs2241423 (MAP2K5), were newly identified as BMI loci by the GIANT study.
- Pubmed
- 22041983
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0208363489333784
- Year of publication
- 2012
Drugs