Annotation Detail

Information
Associated Genes
SMAD4
Associated Variants
SMAD4 p.Arg361Ser (p.R361S) ( ENST00000588745.5, ENST00000398417.6, ENST00000593223.2, ENST00000589941.2, ENST00000714272.1, ENST00000714261.1, ENST00000714269.1, ENST00000714264.1, ENST00000590061.2, ENST00000714266.1, ENST00000588860.6, ENST00000714268.1, ENST00000342988.8, ENST00000714270.1, ENST00000589076.6 )
SMAD4 p.Arg361Gly (p.R361G) ( ENST00000593223.2, ENST00000714269.1, ENST00000588745.5, ENST00000398417.6, ENST00000342988.8, ENST00000714272.1, ENST00000714261.1, ENST00000714268.1, ENST00000590061.2, ENST00000589941.2, ENST00000589076.6, ENST00000588860.6, ENST00000714270.1, ENST00000714264.1, ENST00000714266.1 )
SMAD4 p.Arg361Cys (p.R361C) ( ENST00000588745.5, ENST00000398417.6, ENST00000342988.8, ENST00000590061.2, ENST00000593223.2, ENST00000714261.1, ENST00000714264.1, ENST00000714266.1, ENST00000588860.6, ENST00000589076.6, ENST00000589941.2, ENST00000714268.1, ENST00000714269.1, ENST00000714270.1, ENST00000714272.1 )
SMAD4 p.Arg361Ser (p.R361S) ( ENST00000342988.8, ENST00000398417.6, ENST00000588745.5, ENST00000588860.6, ENST00000589076.6, ENST00000589941.2, ENST00000590061.2, ENST00000593223.2, ENST00000714261.1, ENST00000714264.1, ENST00000714266.1, ENST00000714268.1, ENST00000714269.1, ENST00000714270.1, ENST00000714272.1 )
SMAD4 p.Arg361Gly (p.R361G) ( ENST00000342988.8, ENST00000398417.6, ENST00000588745.5, ENST00000588860.6, ENST00000589076.6, ENST00000589941.2, ENST00000590061.2, ENST00000593223.2, ENST00000714261.1, ENST00000714264.1, ENST00000714266.1, ENST00000714268.1, ENST00000714269.1, ENST00000714270.1, ENST00000714272.1 )
SMAD4 p.Arg361Cys (p.R361C) ( ENST00000714266.1, ENST00000714264.1, ENST00000714261.1, ENST00000593223.2, ENST00000590061.2, ENST00000589941.2, ENST00000589076.6, ENST00000588860.6, ENST00000588745.5, ENST00000398417.6, ENST00000342988.8, ENST00000714270.1, ENST00000714272.1, ENST00000714269.1, ENST00000714268.1 )
Associated Disease
juvenile polyposis syndrome
Source Database
DisGeNET
Description
Mutations in DPC4 (SMAD4) cause juvenile polyposis syndrome, but only account for a minority of cases.
Pubmed
9811934
Original source reporting the Gene Disease association
UNIPROT
DisGENET score for the Gene Disease association
0.587926175215869
Year of publication
1998
Drugs