Annotation Detail
Information
- Associated Genes
- IL23R
- Associated Variants
-
IL23R c.799-3588T>G
(
ENST00000697165.1,
ENST00000697154.1,
ENST00000371007.6,
ENST00000347310.10,
ENST00000425614.3,
ENST00000697163.1,
ENST00000697164.1,
ENST00000697230.1 )
IL23R c.799-3588T>G ( ENST00000347310.10, ENST00000425614.3, ENST00000697154.1, ENST00000697163.1, ENST00000697164.1, ENST00000697165.1, ENST00000697230.1, ENST00000371007.6 ) - Associated Disease
- ulcerative colitis
- Source Database
- DisGeNET
- Description
- The data show an association of both IL23R SNPs with overall IBD (statistically stronger, rs7517847; odds ratio [OR] = 0.79, 95% confidence interval [CI]: 0.67-0.94, minor allele frequencies: 0.355 in IBD patients versus 0.410 in controls; P = 0.005), somewhat stronger in Crohn's disease (OR = 0.74, 95% CI: 0.61-0.91) than in ulcerative colitis (OR = 0.84, 95% CI: 0.69-1.03).
- Pubmed
- 18383521
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.326936272243952
- Year of publication
- 2008
Drugs