Annotation Detail
Information
- Associated Genes
- HTR1A
- Associated Variants
-
HTR1A c.-1019G>C
HTR1A c.-1019G>C - Associated Disease
- Unipolar Depression
- Source Database
- DisGeNET
- Description
- Concerning neuroreceptor PET imaging, decreased 5-HT(1A) binding potential in the raphe, medial temporal lobe, and medial prefrontal cortex (mPFC) has been strongly associated with MDD, and may be impacted by a functional single nucleotide polymorphism in the promoter region of the 5-HT(1A) gene (HTR1A: -1019 C/G; rs6295).
- Pubmed
- 19358877
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0114005586273727
- Year of publication
- 2009
Drugs