Annotation Detail
Information
- Associated Genes
- FEN1
- Associated Variants
-
FEN1 MUTATION
FEN1 MUTATION - Associated Disease
- colorectal cancer
- Source Database
- DisGeNET
- Description
- It is also thought that the product of the APC gene can modulate base excision repair (BER) pathway through an interaction with DNA polymerase β (Pol-β) and flap endonuclease 1 (Fen-1) to mediate CRC cell apoptosis.
- Pubmed
- 26334567
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 5
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00081432561624091
Drugs