Annotation Detail
Information
- Associated Genes
- KDR
- Associated Variants
-
KDR p.Ala1065Thr (p.A1065T)
(
ENST00000263923.5 )
KDR p.Ala1065Thr (p.A1065T) ( ENST00000263923.5 ) - Associated Disease
- Hemangiosarcoma
- Source Database
- DisGeNET
- Description
- Likewise, activating mutations in the receptor tyrosine kinase KDR (VEGFR2) have been reported in angiosarcomas and non-small cell lung cancers; the KDR A1065T mutation is reported to be sensitive to VEGFR kinase inhibitors, and fibroblast growth factor receptor inhibitors are in trials.
- Pubmed
- 25679062
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.121085767488321
- Year of publication
- 2015
Drugs