Annotation Detail

Information
Associated Genes
PAH
Associated Variants
PAH p.Ile65Ser (p.I65S) ( ENST00000553106.6, ENST00000307000.7 )
PAH p.Ile65Thr (p.I65T) ( ENST00000553106.6, ENST00000307000.7 )
PAH p.Ile65Asn (p.I65N) ( ENST00000553106.6, ENST00000307000.7 )
PAH p.Leu48Ser (p.L48S) ( ENST00000307000.7, ENST00000553106.6 )
PAH p.Phe39Leu (p.F39L) ( ENST00000553106.6, ENST00000307000.7 )
PAH p.Ile65Ser (p.I65S) ( ENST00000307000.7, ENST00000553106.6 )
PAH p.Ile65Thr (p.I65T) ( ENST00000307000.7, ENST00000553106.6 )
PAH p.Ile65Asn (p.I65N) ( ENST00000307000.7, ENST00000553106.6 )
PAH p.Leu48Ser (p.L48S) ( ENST00000307000.7, ENST00000553106.6 )
PAH p.Phe39Leu (p.F39L) ( ENST00000307000.7, ENST00000553106.6 )
Associated Disease
Hyperphenylalaninaemia
Source Database
DisGeNET
Description
The F39L, L48S, and I65T PAH mutations were selected because each is associated with a spectrum of in vivo HPA among patients.
Pubmed
10720436
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.152421134909395
Year of publication
2000
Drugs