Annotation Detail
Information
- Associated Genes
- SETD2
- Associated Variants
-
SETD2 MUTATION
SETD2 MUTATION - Associated Disease
- colon carcinoma
- Source Database
- DisGeNET
- Description
- Colon cancer cell response to the BH3-mimetic was unmodified by HIF-1 activation and OBX induced a decrease in HIF-1α protein levels and HIF-1 transcriptional activity, probably by decreasing HIF-1α synthesis and facilitating a VHL-independent proteasomal degradation pathway.
- Pubmed
- 25979228
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 4
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00217153497664243
Drugs