Annotation Detail
Information
- Associated Genes
- PTGS2
- Associated Variants
-
PTGS2 MUTATION
PTGS2 MUTATION - Associated Disease
- Carcinoma of lung
- Source Database
- DisGeNET
- Description
- Silencing of USP22 downregulated COX-2, decreased its half-life, and inhibited lung carcinoma cell proliferation by directly interacting with and modulating the stability and activity of COX-2 through the regulation of its ubiquitination status.
- Pubmed
- 25817787
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 5
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0184580473014606
Drugs