Annotation Detail
Information
- Associated Genes
- HTR2A
- Associated Variants
-
HTR2A MUTATION
HTR2A MUTATION
HTR2A p.His452Tyr (p.H452Y) ( ENST00000543956.5, ENST00000542664.4 )
HTR2A p.Ser34= (p.S34=) ( ENST00000542664.4, ENST00000543956.5 )
HTR2A p.His452Tyr (p.H452Y) ( ENST00000542664.4, ENST00000543956.5 )
HTR2A p.Ser34= (p.S34=) ( ENST00000542664.4, ENST00000543956.5 ) - Associated Disease
- major depressive disorder
- Source Database
- DisGeNET
- Description
- Accordingly, two single nucleotide polymorphisms of the HTR2A gene (rs6314 ie His452Tyr and rs6313 ie 102C/T), which specific allelic variants may decrease 5-HT2AR-mediated transmission (as in Htr2a(-/-)mice), were studied in a sample of 485 Caucasian patients with MDD.
- Pubmed
- 24801750
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.155266375415353
- Year of publication
- 2014
Drugs