Annotation Detail
Information
- Associated Genes
- CYP2E1
- Associated Variants
-
CYP2E1 MUTATION
CYP2E1 MUTATION - Associated Disease
- Carcinogenesis
- Source Database
- DisGeNET
- Description
- The mechanisms by which chronic alcohol consumption enhances carcinogenesis include acetaldehyde (AA) generated by alcohol dehydrogenase and reactive oxygen species (ROS) generated predominantly by cytochrome P450 2E1 (CYP2E1), but also by other factors during inflammation.
- Pubmed
- 25427901
- Section of the abstract supporting the evidence
- ALL_TEXT_1/3
- Number of the section of the abstract supporting the evidence
- 1
- Number of the sentence supporting the evidence
- 1
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00488595369744546
Drugs