Annotation Detail

Information
Associated Genes
CXCR4
Associated Variants
CXCR4 MUTATION
CXCR4 MUTATION
Associated Disease
Osteosarcoma of bone
Source Database
DisGeNET
Description
Our study provides further evidence of the contributions of hypoxia and the HIF-1α/CXCR4 pathway to the progression of osteosarcoma, and suggests that this axis might be efficiently leveraged in the development of novel osteosarcoma therapeutics.
Pubmed
25444927
Section of the abstract supporting the evidence
ALL_TEXT_3/3
Number of the section of the abstract supporting the evidence
3
Number of the sentence supporting the evidence
7
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.00271441872080303
Drugs