Annotation Detail
Information
- Associated Genes
- CYP2C19
- Associated Variants
-
CYP2C19 p.Trp212Ter (p.W212*)
(
ENST00000371321.9 )
CYP2C19 p.Pro227= (p.P227=) ( ENST00000371321.9 )
CYP2C19 p.Pro227= (p.P227=) ( ENST00000371321.9 )
CYP2D6 p.Ala122Val (p.A122V) ( ENST00000359033.4, ENST00000645361.2 )
CYP2D6 p.Ala122Glu (p.A122E) ( ENST00000359033.4, ENST00000645361.2 )
CYP2C19 p.Trp212Ter (p.W212*) ( ENST00000371321.9 )
CYP2C19 p.Pro227= (p.P227=) ( ENST00000371321.9 )
CYP2C19 p.Pro227= (p.P227=) ( ENST00000371321.9 )
CYP2D6 p.Ala122Val (p.A122V) ( ENST00000359033.4, ENST00000645361.2 )
CYP2D6 p.Ala122Glu (p.A122E) ( ENST00000359033.4, ENST00000645361.2 ) - Associated Disease
- Non-small cell lung carcinoma
- Source Database
- DisGeNET
- Description
- CYP2C19*2(G681A), CYP2C19*3(G636A), CYP2D6*4(C188T), CYP2D6*2(C2938T, G4268C), CYP3AP1*3- G44A and CYP3A5*3(A22893G) are the most common polymorphisms detected among Chinese that may influence the efficacy of vinorelbine-based therapies to treat non-small-cell lung cancer (NSCLC).
- Pubmed
- 17450472
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
- Year of publication
- 2007
Drugs