Annotation Detail
Information
- Associated Genes
- CXCR4
- Associated Variants
-
CXCR4 MUTATION
CXCR4 MUTATION - Associated Disease
- Malignant neoplasm of prostate
- Source Database
- DisGeNET
- Description
- Autocrine CXCL8-stimulation (i) increased expression of CXCR1 and CXCR2 in PTEN-deficient CaP cells suggesting a self-potentiating signaling axis and (ii) induced expression of CXCR4 and CCR2 in PTEN-wild-type and PTEN-depleted CaP cells.
- Pubmed
- 24970800
- Section of the abstract supporting the evidence
- ALL_TEXT_1/3
- Number of the section of the abstract supporting the evidence
- 1
- Number of the sentence supporting the evidence
- 3
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0081432561624091
Drugs