Annotation Detail
Information
- Associated Genes
- TIMP1
- Associated Variants
-
TIMP1 MUTATION
TIMP1 MUTATION - Associated Disease
- Fibrosis, Liver
- Source Database
- DisGeNET
- Description
- Hepatocyte growth factor (HGF) gene transfer inhibits liver fibrosis by regulating aberrant cellular functions, while mutant matrix metalloproteinase-9 (mMMP-9) enhances matrix degradation by neutralizing the elevated tissue inhibitor of metalloproteinase-1 (TIMP-1).
- Pubmed
- 25380300
- Section of the abstract supporting the evidence
- UNLABELLED
- Number of the section of the abstract supporting the evidence
- 1
- Number of the sentence supporting the evidence
- 1
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00461451182536516
Drugs