Annotation Detail
Information
- Associated Genes
- PCLO
- Associated Variants
-
PCLO p.Ser4814Ala (p.S4814A)
(
ENST00000333891.14,
ENST00000423517.6,
ENST00000618073.1 )
PCLO p.Ser4814Ala (p.S4814A) ( ENST00000333891.14, ENST00000423517.6, ENST00000618073.1 ) - Associated Disease
- Unipolar Depression
- Source Database
- DisGeNET
- Description
- Recent genetic studies showed evidence for a role of the single-nucleotide polymorphism rs2522833 within the PCLO gene in the etiology of major depression, and rs2522833 has been shown to modulate hypothalamic pituitary adrenal (HPA) axis activity during antidepressant treatment.
- Pubmed
- 22832399
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00244297684872273
- Year of publication
- 2011
Drugs