Annotation Detail
Information
- Associated Genes
- SETD2
- Associated Variants
-
SETD2 MUTATION
SETD2 MUTATION - Associated Disease
- Tumor Progression
- Source Database
- DisGeNET
- Description
- As NSD1 and SETD2 are known tumor suppressors and loss of H4K20 trimethylation is an early event in cancer progression, which contributes to genomic instability, we propose DMAPT as a potent pharmacologic agent that can reverse NF-κB-dependent and -independent cancer-specific epigenetic abnormalities.
- Pubmed
- 25611383
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 10
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00868613990656971
Drugs