Annotation Detail
Information
- Associated Genes
- CTSS
- Associated Variants
-
CTSS MUTATION
CTSS MUTATION - Associated Disease
- Aortic Aneurysm, Abdominal
- Source Database
- DisGeNET
- Description
- In vitro, human abdominal aortic aneurysm vascular smooth muscle cells produced more CTSS and exhibited increased CTSS-derived elastolytic activity than healthy aortic vascular smooth muscle cells, whereas recombinant human osteoprotegerin stimulated CTSS-dependent elastase activity in aortic vascular smooth muscle cells.
- Pubmed
- 25301844
- Section of the abstract supporting the evidence
- APPROACH AND RESULTS
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 8
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
Drugs