Annotation Detail
Information
- Associated Genes
- ZAP70
- Associated Variants
-
ZAP70 MUTATION
ZAP70 MUTATION - Associated Disease
- T-Cell Lymphoma
- Source Database
- DisGeNET
- Description
- In conclusion, a lower expression pattern for all three genes may indicate a weaker immune status based on reduced TCRζ and ZAP-70 expression without the complementary effects of FcɛRIγ, while aberrant TCRζ 3'UTR splicing may contribute to T-cell receptor (TCR) signaling regulation in T cells from patients with T- and NK/T-cell lymphoma.
- Pubmed
- 25513989
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 7
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000542883744160607
Drugs