Annotation Detail
Information
- Associated Genes
- TNFSF10
- Associated Variants
-
HRAS p.Gly12Val (p.G12V)
(
ENST00000397594.7,
ENST00000311189.8,
ENST00000397596.6,
ENST00000417302.7,
ENST00000451590.5 )
HRAS p.Gly12Ala (p.G12A) ( ENST00000397596.6, ENST00000311189.8, ENST00000397594.7, ENST00000417302.7, ENST00000451590.5 )
HRAS p.Gly12Asp (p.G12D) ( ENST00000397596.6, ENST00000417302.7, ENST00000451590.5, ENST00000311189.8, ENST00000397594.7 )
HRAS p.Gly12Val (p.G12V) ( ENST00000311189.8, ENST00000397594.7, ENST00000397596.6, ENST00000417302.7, ENST00000451590.5 )
HRAS p.Gly12Ala (p.G12A) ( ENST00000311189.8, ENST00000397594.7, ENST00000397596.6, ENST00000417302.7, ENST00000451590.5 )
HRAS p.Gly12Asp (p.G12D) ( ENST00000311189.8, ENST00000397594.7, ENST00000397596.6, ENST00000417302.7, ENST00000451590.5 ) - Associated Disease
- Carcinogenesis
- Source Database
- DisGeNET
- Description
- We found that TRAIL expression is consistently downregulated in HRAS(G12V)-transformed cells in stepwise tumorigenesis models derived from four different tissues due to DNA hypermethylation of CpG clusters within the TRAIL promoter.
- Pubmed
- 21697397
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00325730246496364
- Year of publication
- 2011
Drugs