Annotation Detail
Information
- Associated Genes
- DRD3
- Associated Variants
-
ADRA2A c.-1252G>C
SNAP25 c.*239G>T ( ENST00000254976.7, ENST00000304886.6, ENST00000685131.1, ENST00000687785.1, ENST00000689757.1, ENST00000689858.1, ENST00000690812.1, ENST00000691161.1, ENST00000691353.1, ENST00000691665.1, ENST00000692411.1, ENST00000693325.1, ENST00000706269.1 )
DRD3 p.Gly9Ser (p.G9S) ( ENST00000295881.9, ENST00000383673.5, ENST00000460779.5, ENST00000467632.5 )
DBH c.1024+192T>C ( ENST00000393056.8 )
ADRA2A c.-1252G>C
SNAP25 c.*239G>T ( ENST00000254976.7, ENST00000304886.6, ENST00000685131.1, ENST00000687785.1, ENST00000689757.1, ENST00000689858.1, ENST00000690812.1, ENST00000691161.1, ENST00000691353.1, ENST00000691665.1, ENST00000692411.1, ENST00000693325.1, ENST00000706269.1 )
DRD3 p.Gly9Ser (p.G9S) ( ENST00000295881.9, ENST00000383673.5, ENST00000460779.5, ENST00000467632.5 )
DBH c.1024+192T>C ( ENST00000393056.8 ) - Associated Disease
- schizophrenia
- Source Database
- DisGeNET
- Description
- Association was also evaluated by considering the polymorphisms as interactions; in this case, a likelihood ratio test (LRT) revealed evidence for association with schizophrenia in four polymorphism combinations: two DRD3*SNAP-25 combinations (rs6280*rs3746544 and rs6280*rs3746544, P=0.02), one ADRA2A*SNAP25 combination (rs1800544*rs3746544) and one ADRA2A*DBH combination (rs1800544*rs2519152).
- Pubmed
- 22940547
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.26447076498633
- Year of publication
- 2013
Drugs