Annotation Detail
Information
- Associated Genes
- ARID1A
- Associated Variants
-
ARID1A MUTATION
ARID1A MUTATION - Associated Disease
- ovarian carcinoma
- Source Database
- DisGeNET
- Description
- Here we show that inhibition of the EZH2 methyltransferase acts in a synthetic lethal manner in ARID1A-mutated ovarian cancer cells and that ARID1A mutational status correlated with response to the EZH2 inhibitor.
- Pubmed
- 25686104
- Section of the abstract supporting the evidence
- ALL_TEXT_2/3
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 4
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00271441872080303
Drugs