Annotation Detail
Information
- Associated Genes
- UGT1A1
- Associated Variants
-
UGT1A1 MUTATION
UGT1A1 MUTATION - Associated Disease
- obesity
- Source Database
- DisGeNET
- Description
- Our study demonstrates that reduced hepatic Ugt1a activity during obesity likely contributes to reduced glucuronidation, and results in higher levels of the toxic metabolite, SN-38.
- Pubmed
- 26334566
- Section of the abstract supporting the evidence
- SIGNIFICANCE
- Number of the section of the abstract supporting the evidence
- 4
- Number of the sentence supporting the evidence
- 13
- Original source reporting the Gene Disease association
- BeFree,GAD
- DisGENET score for the Gene Disease association
- 0.00318135759484294
Drugs