Annotation Detail

Information
Associated Genes
DRD4
Associated Variants
DRD4 MUTATION
DRD4 MUTATION
Associated Disease
Nicotine withdrawal
Source Database
DisGeNET
Description
Brain systems associated with reward salience may become primed and overreactive at nicotine replacement doses intended for the first step of smoking cessation and may become inhibited during nicotine withdrawal in DRD4 S but not in DRD4 L carriers.
Pubmed
24659022
Section of the abstract supporting the evidence
CONCLUSIONS
Number of the section of the abstract supporting the evidence
4
Number of the sentence supporting the evidence
7
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.000271441872080303
Drugs