Annotation Detail
Information
- Associated Genes
- NOS2
- Associated Variants
-
NOS2 c.468-704A>T
(
ENST00000313735.11,
ENST00000697339.1,
ENST00000646938.1 )
ENSG00000266202 c.220-3344G>A
SLC11A1 c.393+14G>C ( ENST00000233202.11 )
SLC11A1 c.393+14G>T ( ENST00000233202.11 )
SLC11A1 c.572-80C>T ( ENST00000233202.11 )
TLR2 c.-1409+324T>C ( ENST00000260010.7, ENST00000642580.1, ENST00000642700.2, ENST00000643501.2, ENST00000646219.2, ENST00000646900.2, ENST00000714431.1, ENST00000714432.1, ENST00000714433.1, ENST00000714434.1, ENST00000714435.1, ENST00000714436.1 )
NOS2 c.468-704A>T ( ENST00000313735.11, ENST00000646938.1, ENST00000697339.1 )
ENSG00000266202 c.220-3344G>A
SLC11A1 c.393+14G>C ( ENST00000233202.11 )
SLC11A1 c.393+14G>T ( ENST00000233202.11 )
SLC11A1 c.572-80C>T ( ENST00000233202.11 )
TLR2 c.-1409+324T>C ( ENST00000260010.7, ENST00000642580.1, ENST00000642700.2, ENST00000643501.2, ENST00000646219.2, ENST00000646900.2, ENST00000714431.1, ENST00000714432.1, ENST00000714433.1, ENST00000714434.1, ENST00000714435.1, ENST00000714436.1 ) - Associated Disease
- Active tuberculosis
- Source Database
- DisGeNET
- Description
- Multilocus analyses between polymorphisms in SLC11A1 and 11 TB candidate genes detected interactions between SLC11A1 and inducible nitric oxide synthase (NOS2A) in Caucasians (rs3731863 [SLC11A1] x rs8073782 [NOS2A], P = 0.009; rs3731863 [SLC11A1] x rs17722851 [NOS2A], P = 0.007) and toll-like receptor 2 (TLR2) in African-Americans (rs3731865 [SLC11A1] x rs1816702, P = 0.005).
- Pubmed
- 19723394
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.000271441872080303
- Year of publication
- 2009
Drugs