Annotation Detail
Information
- Associated Genes
- PTGS2
- Associated Variants
-
PTGS2 MUTATION
PTGS2 MUTATION - Associated Disease
- Neoplasm Metastasis
- Source Database
- DisGeNET
- Description
- Cyclooxygenase-2 (COX-2) and interleukin-8 (IL-8) are two highly expressed inflammatory mediators to be induced by the protein kinase C (PKC) signaling via various inflammatory stimuli and both contribute significantly to cancer metastasis/progression.
- Pubmed
- 25754990
- Section of the abstract supporting the evidence
- ALL_TEXT_1/3
- Number of the section of the abstract supporting the evidence
- 1
- Number of the sentence supporting the evidence
- 2
- Original source reporting the Gene Disease association
- BeFree,CTD_human,GAD,LHGDN,RGD
- DisGENET score for the Gene Disease association
- 0.268737890069494
Drugs