Annotation Detail
Information
- Associated Genes
- STAT1
- Associated Variants
-
STAT1 MUTATION
STAT1 MUTATION - Associated Disease
- Mycoses
- Source Database
- DisGeNET
- Description
- The current studies demonstrate that infection with C. neoformans strain H99γ in mice with macrophage-specific STAT1 ablation resulted in severely increased inflammation of the pulmonary tissue, a dysregulated Th1/Th2-type immune response, increased fungal burden, deficient M1 macrophage activation, and loss of protection.
- Pubmed
- 26351277
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 5
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00135720936040152
Drugs