Annotation Detail
Information
- Associated Genes
- MTRR
- Associated Variants
-
MTHFD1 p.Lys134Arg (p.K134R)
(
ENST00000557539.2,
ENST00000554768.6,
ENST00000697174.1,
ENST00000545908.6,
ENST00000697173.1,
ENST00000697168.1,
ENST00000652337.1,
ENST00000557370.3 )
MTR c.*1488T>C ( ENST00000674797.2, ENST00000366577.10 )
FASTKD3 p.Lys56Arg (p.K56R) ( ENST00000264669.10 )
FASTKD3 p.Lys56Thr (p.K56T) ( ENST00000264669.10 )
DHFR c.-473T>C, MSH3 p.Ile79Val (p.I79V) ( ENST00000439211.7, ENST00000265081.7, ENST00000667069.1 )
MTHFD1 p.Lys134Arg (p.K134R) ( ENST00000545908.6, ENST00000554768.6, ENST00000557370.3, ENST00000557539.2, ENST00000652337.1, ENST00000697168.1, ENST00000697173.1, ENST00000697174.1 )
MTR c.*1488T>C ( ENST00000366577.10, ENST00000674797.2 )
FASTKD3 p.Lys56Arg (p.K56R) ( ENST00000264669.10 )
FASTKD3 p.Lys56Thr (p.K56T) ( ENST00000264669.10 )
DHFR c.-473T>C, MSH3 p.Ile79Val (p.I79V) ( ENST00000439211.7, ENST00000265081.7, ENST00000667069.1 ) - Associated Disease
- Non-small cell lung carcinoma
- Source Database
- DisGeNET
- Description
- Variant alleles were significantly associated with favorable survivals of NSCLC for MTR rs3768160 A>G (allelic hazards ratio [HR], 0.78; 95% confidence interval [CI], 0.62-0.98), MTRR rs2966952 G>A (allelic HR, 0.84; 95% CI, 0.71-0.99) and DHFR rs1650697 G>A (allelic HR, 0.83; 95% CI, 0.70-0.99) and with unfavorable prognosis for MTHFD1 rs1950902 G>A with borderline significance (allelic HR, 1.18; 95% CI, 0.99-1.40).
- Pubmed
- 20737570
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00290991572276264
- Year of publication
- 2010
Drugs