Annotation Detail

Information
Associated Genes
IL10RB
Associated Variants
IL10 c.378+19T>C ( ENST00000664374.2, ENST00000659065.2, ENST00000471071.2, ENST00000656872.2, ENST00000659997.3, ENST00000659642.2, ENST00000423557.1 )
IL19 c.-149+1984T>G ( ENST00000659642.2, ENST00000659997.3, ENST00000656872.2, ENST00000659065.2, ENST00000664374.2 )
IL19 c.-149+2211A>G ( ENST00000664374.2, ENST00000659065.2, ENST00000659642.2, ENST00000659997.3, ENST00000656872.2 )
IFNAR2-IL10RB c.*85A>G, IL10RB c.*85A>G ( ENST00000290200.7, ENST00000609556.3, ENST00000637650.2, ENST00000433395.7 )
rs7281762 ( ENST00000609556.3, ENST00000637650.2 )
TGFBR2 p.Asn414= (p.N414=) ( ENST00000295754.10, ENST00000359013.4, ENST00000714389.1, ENST00000714390.1, ENST00000714391.1 )
NC_000003.12:g.30694445G>A
IL6 c.-85+344A>G ( ENST00000404625.5 )
IL10 c.378+19T>C ( ENST00000423557.1, ENST00000471071.2, ENST00000659065.2, ENST00000659642.2, ENST00000664374.2, ENST00000656872.2, ENST00000659997.3 )
IL19 c.-149+1984T>G ( ENST00000659065.2, ENST00000659642.2, ENST00000664374.2, ENST00000656872.2, ENST00000659997.3 )
IL19 c.-149+2211A>G ( ENST00000659065.2, ENST00000659642.2, ENST00000664374.2, ENST00000656872.2, ENST00000659997.3 )
IFNAR2-IL10RB c.*85A>G, IL10RB c.*85A>G ( ENST00000290200.7, ENST00000609556.3, ENST00000637650.2, ENST00000433395.7 )
rs7281762 ( ENST00000609556.3, ENST00000637650.2 )
TGFBR2 p.Asn414= (p.N414=) ( ENST00000295754.10, ENST00000359013.4, ENST00000714389.1, ENST00000714390.1, ENST00000714391.1 )
NC_000003.12:g.30694445G>A
IL6 c.-85+344A>G ( ENST00000404625.5 )
Associated Disease
leprosy
Source Database
DisGeNET
Description
Significant associations (P < .05) were observed for 8 polymorphisms (rs1800871, rs1800872, and rs1554286 of IL-10; rs3171425 and rs7281762 of IL-10RB; rs2228048 and rs744751 of TGFBR2; and rs1800797 of IL-6) with leprosy.
Pubmed
21917900
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.000271441872080303
Year of publication
2011
Drugs