Annotation Detail
Information
- Associated Genes
- CREB1
- Associated Variants
-
GNB3 p.Ser275= (p.S275=)
(
ENST00000435982.6,
ENST00000229264.8,
ENST00000422785.7 )
HTR2A p.Asp172= (p.D172=) ( ENST00000543956.5, ENST00000542664.4 )
HTR2A c.-329+609G>A
ADCY9 p.Ile772Met (p.I772M) ( ENST00000294016.8 )
PDE1A c.215+11424C>T ( ENST00000351439.10, ENST00000409365.6, ENST00000410103.2, ENST00000435564.6, ENST00000482782.6, ENST00000495511.2 )
rs255163
GNB3 p.Ser275= (p.S275=) ( ENST00000229264.8, ENST00000435982.6, ENST00000422785.7 )
HTR2A p.Asp172= (p.D172=) ( ENST00000542664.4, ENST00000543956.5 )
HTR2A c.-329+609G>A
ADCY9 p.Ile772Met (p.I772M) ( ENST00000294016.8 )
PDE1A c.215+11424C>T ( ENST00000351439.10, ENST00000409365.6, ENST00000410103.2, ENST00000435564.6, ENST00000482782.6, ENST00000495511.2 )
rs255163 - Associated Disease
- Unipolar Depression
- Source Database
- DisGeNET
- Description
- To explore the possible relationship between six single nucleotide polymorphisms (SNPs) (rs6311 and rs6305 of 5-HT2A, rs5443 of Gβ3, rs2230739 of ACDY9, rs1549870 of PDE1A and rs255163 of CREB1, which are all related with 5-HT2A the signal transduction pathway) and the response efficacy to selective serotonin reuptake inhibitor (SSRI) treatments in major depressive disorder (MDD) Chinese.
- Pubmed
- 22480177
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00651460492992728
- Year of publication
- 2012
Drugs