Annotation Detail
Information
- Associated Genes
- HTR2A
- Associated Variants
-
TPH1 c.803+221C>A
(
ENST00000250018.6,
ENST00000682019.1,
ENST00000528338.2,
ENST00000714230.1 )
TPH2 c.608+9108T>C ( ENST00000333850.4 )
HTR2A c.614-2211T>C ( ENST00000543956.5, ENST00000542664.4 )
HTR2A p.Ser34= (p.S34=) ( ENST00000542664.4, ENST00000543956.5 )
HTR2A c.-329+609G>A
HTR6 p.Tyr89= (p.Y89=) ( ENST00000289753.2 )
HTR1A c.-1019G>C
TPH1 c.803+221C>A ( ENST00000250018.6, ENST00000528338.2, ENST00000682019.1, ENST00000714230.1 )
TPH2 c.608+9108T>C ( ENST00000333850.4 )
HTR2A c.614-2211T>C ( ENST00000542664.4, ENST00000543956.5 )
HTR2A p.Ser34= (p.S34=) ( ENST00000542664.4, ENST00000543956.5 )
HTR2A c.-329+609G>A
HTR6 p.Tyr89= (p.Y89=) ( ENST00000289753.2 )
HTR1A c.-1019G>C - Associated Disease
- major depressive disorder
- Source Database
- DisGeNET
- Description
- In this study, we evaluated the association of seven serotonin signal transduction-linked single nucleotide polymorphisms [HTR1A (rs6295), HTR2A (rs6313, rs6311 and rs7997012), HTR6 (rs1805054), TPH1 (rs1800532) and TPH2 (rs1386494)] with major depressive disorder and/or treatment outcome with serotonin reuptake inhibitors.
- Pubmed
- 19590397
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.155266375415353
- Year of publication
- 2009
Drugs