Annotation Detail

Information
Associated Genes
RB1
Associated Variants
RB1 p.Tyr606Ter (p.Y606*) ( ENST00000713858.1, ENST00000713857.1, ENST00000650461.1, ENST00000267163.6, ENST00000713856.1 )
RB1 p.Tyr606Ter (p.Y606*) ( ENST00000267163.6, ENST00000650461.1, ENST00000713856.1, ENST00000713857.1, ENST00000713858.1 )
Associated Disease
retinoblastoma
Source Database
DisGeNET
Description
To describe the documented growth, clinical course, and histopathology of retinoblastomas in an untreated and otherwise normal right eye of a 27-year-old white male with a g.153211T>A (p.Tyr606X) mutation in the retinoblastoma 1 gene, whose left eye was enucleated at age 2 years for 2 retinoblastomas.
Pubmed
16631255
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.499992532686291
Year of publication
2006
Drugs