Annotation Detail
Information
- Associated Genes
- SETD2
- Associated Variants
-
SETD2 MUTATION
SETD2 MUTATION - Associated Disease
- leukemia
- Source Database
- DisGeNET
- Description
- Histone methyltransferases, including MLL1, DOT1L, EZH2, and SETD2 are recurrently deregulated in human leukemia, either directly by gene mutations or balanced translocations, or indirectly as components of protein complexes that are disturbed in leukemia due to alterations of the other components in these complexes.
- Pubmed
- 25592767
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 6
- Original source reporting the Gene Disease association
- BeFree,CTD_human
- DisGENET score for the Gene Disease association
- 0.121357209360402
Drugs