Annotation Detail
Information
- Associated Genes
- MTTP
- Associated Variants
-
MTTP MUTATION
MTTP MUTATION - Associated Disease
- Hypercholesterolemia, Familial
- Source Database
- DisGeNET
- Description
- New therapies such as mipomersen, a second-generation antisense oligonucleotide, microsomal triglyceride transfer protein inhibitors that decrease the synthesis of apolipoprotein B-containing lipoproteins and proprotein convertase subtilisin/kexin type 9 inhibitors hold promise in reducing cholesterol levels in those patients in whom low density lipoprotein cholesterol (LDL-C) reduction is required beyond the use of statins, especially in those with severe heterozygous familial hypercholesterolaemia or homozygous familial hypercholesterolaemia.
- Pubmed
- 24870549
- Section of the abstract supporting the evidence
- RECENT FINDINGS
- Number of the section of the abstract supporting the evidence
- 2
- Number of the sentence supporting the evidence
- 8
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00271441872080303
Drugs