Annotation Detail

Information
Associated Genes
HLA-A
Associated Variants
TP53 p.Val157Phe (p.V157F) ( ENST00000576024.2, ENST00000604348.6, ENST00000510385.5, ENST00000445888.6, ENST00000504937.5, ENST00000455263.6, ENST00000269305.9, ENST00000359597.8, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1, ENST00000413465.6, ENST00000420246.6, ENST00000504290.5, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1 )
TP53 p.Val157Ile (p.V157I) ( ENST00000604348.6, ENST00000510385.5, ENST00000504937.5, ENST00000455263.6, ENST00000504290.5, ENST00000576024.2, ENST00000610623.4, ENST00000269305.9, ENST00000359597.8, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000714356.1, ENST00000714357.1, ENST00000610292.4, ENST00000610538.4, ENST00000618944.4, ENST00000619186.4, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 )
WRAP53 p.Ser149Cys (p.S149C) ( ENST00000316024.9, ENST00000698742.1, ENST00000396463.7, ENST00000457584.6, ENST00000431639.6, ENST00000534050.5, ENST00000698746.1 )
TP53 p.Val157Phe (p.V157F) ( ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 )
TP53 p.Val157Ile (p.V157I) ( ENST00000269305.9, ENST00000359597.8, ENST00000413465.6, ENST00000420246.6, ENST00000445888.6, ENST00000455263.6, ENST00000504290.5, ENST00000504937.5, ENST00000510385.5, ENST00000576024.2, ENST00000604348.6, ENST00000610292.4, ENST00000610538.4, ENST00000610623.4, ENST00000618944.4, ENST00000619186.4, ENST00000619485.4, ENST00000620739.4, ENST00000622645.4, ENST00000714356.1, ENST00000714357.1, ENST00000714359.1, ENST00000714408.1, ENST00000714409.1 )
WRAP53 p.Ser149Cys (p.S149C) ( ENST00000316024.9, ENST00000396463.7, ENST00000431639.6, ENST00000457584.6, ENST00000534050.5, ENST00000698742.1, ENST00000698746.1 )
Associated Disease
squamous cell carcinoma
Source Database
DisGeNET
Description
Previous analyses of p53 in 40 HLA-A*0201(HLA-A2)(+) squamous cell carcinomas of the head and neck (SCCHN) indicated that 6/13 p53 missense mutations that were detected, S149C, T150R, V157F, Y220C, Y220H and E271K, occurred within HLA-A2-restricted cytotoxic T lymphocyte (CTL)-defined p53 epitopes.
Pubmed
17294448
Original source reporting the Gene Disease association
BeFree
DisGENET score for the Gene Disease association
0.00318135759484294
Year of publication
2007
Drugs