Annotation Detail
Information
- Associated Genes
- ADRB2
- Associated Variants
-
LEPR p.Gln223Arg (p.Q223R)
(
ENST00000344610.12,
ENST00000371058.1,
ENST00000371060.7,
ENST00000616738.4,
ENST00000371059.7,
ENST00000349533.11 )
ADRB2 p.Gly16Arg (p.G16R) ( ENST00000305988.6 )
LEPR p.Gln223Arg (p.Q223R) ( ENST00000344610.12, ENST00000349533.11, ENST00000371058.1, ENST00000371059.7, ENST00000371060.7, ENST00000616738.4 )
ADRB2 p.Gly16Arg (p.G16R) ( ENST00000305988.6 ) - Associated Disease
- Overweight
- Source Database
- DisGeNET
- Description
- Together, our findings suggest evidence for a two-locus interaction between the LEPR Gln223Arg and ADRB2 Arg16Gly variants in the risk of overweight/obesity, and highlight further the importance of multilocus effects in the genetic component of obesity.
- Pubmed
- 21233811
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.0108253372748096
- Year of publication
- 2011
Drugs