Annotation Detail
Information
- Associated Genes
- EPHB2
- Associated Variants
-
EPHB2 MUTATION
EPHB2 MUTATION - Associated Disease
- colorectal carcinoma
- Source Database
- DisGeNET
- Description
- In conclusion, PXN promotes Bcl-2 phosphorylation at Serine 87 via PXN-mediated ERK activation, and its stabilization associated with increased tumor formation efficacy in mice and poor patient outcome in colorectal cancer patients.
- Pubmed
- 25826088
- Section of the abstract supporting the evidence
- ALL_TEXT_3/3
- Number of the section of the abstract supporting the evidence
- 3
- Number of the sentence supporting the evidence
- 6
- Original source reporting the Gene Disease association
- BeFree
- DisGENET score for the Gene Disease association
- 0.00977190739489092
Drugs